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Antibody Subsets

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Antibody SubsetsMore than 95% of kidney disease are related to immune system disorder, both antibody test and lymphocyte subpopulation test are used to find the primary cause of kidneys and detect the very beginning sign of kidney damage.

Antoantibody Test

Antoantibody test helps to figure out: whether your kidney damages are caused by autoimmune disorder, how serious your autoimmune disease is and specific drugs and cleaning method to deal with the excessive antibodies in your body.

This test including more than 10 lab values.

ANA: Many rheumatic diseases have similar signs and symptoms — joint pain, fatigue and fever. While an ANA test can't confirm a specific diagnosis, it can rule out some possible diseases. And if the ANA test is positive, your blood can be tested for the presence of particular antinuclear antibodies, some of which are specific to certain diseases.

Anti-dsDNA: When you have symptoms associated with SLE and a positive ANA test; periodically when you have been diagnosed with SLE.

Anti-Smith: This test measures the amount of antibodies to Smith antigen in blood. It is used to diagnose and manage systemic lupus erythematosus (SLE) It is also used in the diagnosis of SLE glomerulonephritis syndrome.

Anti-SS-A, Anti-SS-B, and Anti-SS-C Antibodies are blood tests that are mainly used to diagnose Sjogren's syndrome, a disease process that results in extreme dryness of the mouth and eyes. Sjogren's syndrome can occur either alone or along with rheumatoid arthritis (RA) or SLE (systemic lupus erythmatosis).

Anti-RNP: A negative anti-RNP antibody result is defined as less than 20 U based on enzyme-linked immunoassay (ELISA).

Anti-Jo-1: a measurement of autoantibodies that are specific for histidyl-tRNA synthetase, also known as Jo-1; found in up to 25% of patients with myositis. This cytoplasmic enzyme catalyzes the esterification of histidine to its cognate tRNA. Binding of anti-Jo-1 antibodies is localized to the cytoplasm of various cell types and the binding can be visualized by immunofluorescence. The test used to detect the autoantibodies in serum is usually an enzyme-linked immunosorbent assay.

Scl-70: Evaluating patients with signs and symptoms of scleroderma and other connective tissue diseases in whom the test for antinuclear antibodies is positive.

Anti-MPO: The Anti-MPO ELISA by ORGENTEC detects antibodies against myeloperoxidase (MPO), one of the target antigens of pANCA. MPO antibodies are specific markers for microscopic polyangiitis (MPA).

It is in the early diagnosis of MPA that the detection of anti-MPO is of great importance; by this means, MPA can be differentiated from other autoimmune diseases with pulmorenal syndrome.

Protease 3: PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Anti-M2 Antibody: it is used for establishing the diagnosis of primary biliary cirrhosis.

Anti-PM-ScI Antibody: Anti-polymyositis/scleroderma-100 (anti-PM/Scl-100) IgG antibodies were originally described in patients with PM/Scl overlap syndrome and are considered rare markers for this and other connective tissues diseases.

The other tests for Antoantibody also includes Anti-ACA, Anti-PCNA Antibody, Anti-histone Antibody, Anti-Rib-P Antibody etc. Doctor recommend each of them for different use in patients’ diagnosis. If you need more information about antibody test, you can email to renal-disease@hotmail.com for a free reply.


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