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IgA Nephropathy is the most common glomerulonephritis throughout the world nowadays. It is characterized by deposition of the IgA antibody in the glomerulus. IgA nephropathy can occur at any age, even in childhood. Although found all over the world, it is more common among Caucasians and Asians. If you among this group, it must be helpful to know the etiologies of IgA nephropathy.
Infections, such as cold, fever or tonsillitis, are common causes of IgA nephropathy. They all can lead to the gross hematuria or urine occult blood.
2. Kidney mesangial cells involved in inflammatory reaction of IgA nephropathy
At the beginning of the disease, the glomerular mesangial cells of IgA patients which stimulated by inflammation produce inflammatory factors. Thus, a large number of immune complex deposit in the kidney, eventually lead to IgA Nephropathy.
3. Genetic factors
Investigation found that part of the IgA nephropathy patients has familial aggregation. It suggests that the disease has a genetic predisposition to a certain extent. So if your family suffers from this disease, you must pay attention to your own physical condition and check regularly.
4. Abnormal IgA immune complex involved in the disease
Glomerular mesangial area of patient deposits a large number of immune complexes. Among them, the main immune complex is the IgA and glomerular mesangial cells which with high affinity. Their combination can lead to phenotype transdifferentiation of the inherent cells, and then result in the IgA Nephropathy.
About 25 percent of adults with IgA nephropathy develop to total Kidney Failure. Symptoms of kidney failure include swelling in the hands and feet, nausea, fatigue, headaches, and sleep problems. By the time these symptoms occur, total kidney failure is near. Thus, people have above symptoms may need dialysis or kidney transplant. But, now these two therapies are not irreplaceable for their side effects.
If you want to know more information about these therapies, you can leave a message below.
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