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Home > Understanding Kidney Disease > Kidney Diseases > CKD > CKD Symptoms >

Fatigue: Why Do Patients with End-Stage Kidney Disease Get Fatigue

2013-11-02 11:58| Font Size A A A

Fatigue: Why Do Patients with End-Stage Kidney Disease Get FatiguePatients with end-stage kidney disease will suffer a series of complications with the lowered kidney function, such as nausea, vomiting, swelling, itchy skin and so on. Fatigue is one of the complications of chronic kidney disease and it is more obvious for patients with end-stage kidney disease. So why do patients with end-stage kidney disease get fatigue?

The kidney function declines to 15% or even less when one goes into end-stage kidney disease. As a consequence, the filtration function, the main function of kidney, is decreased. So the waste products and toxins that generate in our body cannot be discharged. When they accumulate to some extend, further kidney damage will follow. The accumulation of toxins contributes a lot to fatigue. The followings are the specific explanations.

High creatinine level.

Creatinine is one of the toxins of muscles metabolism, which should be discharged out through the blood. But with damaged kidney, the creatinine cannot be well filtrated . When they reach a certain concentration, fatigue will occur.


Anemia is the leading cause of fatigue. How does anemia attack? What toxins are related to this symptom?

a. Guanidine toxin. Guanidine is one of the toxins that stays in the blood because of severe kidney damage. Its buildup in the blood will lead to anemia.

b. Polyamine. High concentration of polyamine is thought to have a bad effect on the production of EPO, which will result in the reduction of red blood cell. Consequently, there will be inadequate supply of blood. This is why anemia appears.

c. Endocrine hormone. The high level of the endocrine hormone is also a contributor to anemia.

The aforementioned information explains why do patients with end-stage kidney disease get fatigue. So the main task to get rid of fatigue for patients with end-stage kidney disease is to remove the toxins. Do you want to know how to remove toxins in your body? You can send an email to or leave a message below, the kidney expert will give a specific suggestion.

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